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Both the low expression of Keap1 and the overexpression of Nrf2 led to a significant increase in xCT mRNA levels (up to a 5-fold increase), which subsequently reduced ROS formation

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Oliveira KRHM, dos Anjos LM, Arajo APS, Luz WL, Kauffmann N, Braga DV, da Conceio Fonseca Passos A, de Moraes SAS, de Jesus Oliveira Batista E, Herculano AM (2019) Ascorbic acid prevents chloroquine-induced toxicity in inner glial cells