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Our findings demonstrate that SRN-901 administration significantly increases the lifespan of mice, reduces frailty scores, modulates proteomic and gene expression pathways linked to longevity and aging-related diseases, and inhibits metabolic aging, the Seragon researchers wrote.

Type 2 innate lymphoid cells (ILC2s) modulate ferroptosis via activating transcription factor 4 (ATF4), which regulates GPX4 expression (115)

In fact, mitochondria contain a large number of proteins, from those involved in energy metabolism, solute transport, ROS production, to inducers of apoptosis, antioxidant defense, and those responsible for mitochondrial dynamics, that are targeted by S-glutathionylation

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