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In one study, specific ablation of osteocytes using an inducible osteocyte-specific diphtheria toxin gene resulted in increased osteoclast activity, reduced BFR, and a blunted response to skeletal unloading with respect to further increases in osteoclast activity and decrements in BFR

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Meanwhile, the efficacy of this pathway can potentially be modulated by the biochemical nature of sialic acids present (Neu5Ac vs