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This results in an accumulation of lymphocytes, splenomegaly, multilineage cytopenias, lymphadenopathy, hepatomegaly, and an increased risk of B-cell lymphoma

An estimate of the logarithmically transformed expression level of each gene based on the intensity of the different probe sets was obtained using the RMA method (robust multi-array analysis [71]) with standard settings (for example quantile normalization and calculation of expressions levels using median polish)

Current best practice emphasizes individualized blood pressure targets based on continuous autoregulation monitoring when available, as this approach maintains cerebral perfusion within patient-specific optimal ranges (73)

Advanced gene knockout studies, single-cell sequencing and bioinformatics analyses have yielded important insights into positive and negative regulators of oligodendrocyte lineage development