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doi: 10.1111/1346-8138.15284 20 HuangWRenFLuoLZhouJHuangDTangL

Common side effects of Melanotan II include nausea, facial flushing, cardiovascular effects, and risk of priapism (prolonged erection requiring emergency care)

Although additional studies are required to clarify the molecular mechanisms responsible for hyperhomocysteinemia-induced vascular disorders, there is evidence that the direct cytotoxicity of markedly elevated homocysteine and/or of its oxidized by-products (homocysteine thiolactone, homocysteine sulfinic acid, and homocysteic acid) damages endothelial cells (Dudman et al, 1991