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The worms are then incubated in a Hepes buffer solution supplemented with these vesicles ( Fig

( n = 120) showed LV dilatation (16%) and ventricular arrhythmias (25%), even in the absence of significant volume overload, suggesting another pathophysiological mechanism ( Besides focal fibrosis, limited data are available regarding the presence of diffuse interstitial fibrosis in patients with MVP, which can be associated with diastolic and systolic impairment