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The monarchE trial at ESMO 2025 (NCT03155997) has achieved a key milestone in the management of hormone receptorpositive (HR+), HER2-negative, node-positive, high-risk early breast cancer (EBC)

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This episode also includes an audience Q&A

While current treatmentsincluding surgery, hormonal therapy, and ARToffer varying success depending on disease stage and phenotype, emerging strategies such as immunotherapy, ferroptosis modulation, and microbiota-based interventions show promise