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doi: 10.1001/jamaneurol.2017.3098 8 BovJ.Martnez-VicenteM.DehayB.PerierC.RecasensA.BombrunA.et al

(2020) 32:e13884

Equol producers exhibited weight growth, while nonproducers experienced decreased blood pressure

The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events