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doi: 10.3389/fphar.2023.1254317 123 van de BoolCRuttenEPAvan HelvoortAFranssenFMEWoutersEFMScholsAMWJ

Low NAD+ levels are associated with ageing and being more prone to chronic diseases such as diabetes, heart disease, Alzheimers disease and vision loss

Although antioxidants may save normal cells from oxidative harm, excessive antioxidant activity may disrupt therapeutic lipid peroxidation, diminishing the effectiveness of therapies that use this process to target cancer cells

To address these limitations, Cruz-Nova and co-researchers developed a novel treatment system using PLGA NPs encapsulating regorafenib, which were then functionalized with CXCR4L and radiolabelled with the therapeutic isotope lutetium-177 ( 1 Lu)