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As the oxidative burden on the mitochondria is lifted, these organelles can begin to shift away from inefficient anaerobic glycolysis (which produces the brain-fog-inducing lactate) and back toward efficient aerobic ATP production

Therefore, multi-target ferroptosis modulators and nanomaterial technologies have been investigated in an attempt to target ferroptosis more effectively in vivo

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(1) Glucose-based productivity is based on the consumption of glucose to produce ATP for glutamate production