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For patients with unexplained mental and motor developmental delay, seizures, recurrent acute encephalopathy, and systemic multisystem manifestations, it is important to conduct early diagnostic investigations such as cranial MRI, EEG, plasma amino acid metabolism, urine organic acid metabolism analysis, CSF metabolism, and genetic testing to clarify the diagnosis

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Ethics statement The animal study was reviewed and approved by The calf and mouse study were reviewed and approved by the Veterinary Science Animal Care Committee of the University of Calgary, protocols AC18-0059 and AC17-0220, respectively

Whether occurring constantly or intermittently, low back pain can significantly impair an individuals ability to function in their day-to-day life