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Collectively, these findings represent the first exploration of the role of cell-penetrable itaconate esters in microglia activation within the context of HAND-CUD models

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Notably, some agents may possess nasal mucosa toxicity, thus, the toxicity evaluation is needed before intranasal administration

(1-5) This form of carnitine can also cross the blood-brain barrier and guard against oxidative damage and against toxins, like amyloid-beta peptide, in the brain