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A stress can trigger the release of Corticotropin-Releasing Hormone (CRH) by the hypothalamus, inducing the immediate production of AdrenoCorticoTropic Hormone (ACTH) by the pituitary, triggering in turn the release by the adrenal gland in the blood of adrenaline and cortisol

36 heavily treated pMMR/MSS CRC patients were enrolled and received 40 mg QD of cabozantinib and 1,500 mg IV every 4 weeks (Q4W) of durvalumab in the phase II CRC cohort of the CAMILLA study

These side effects are usually temporary and resolve on their own

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