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These changes contribute to neuroinflammation, bloodbrain barrier (BBB) dysfunction, microglial activation, and neurotransmitter imbalances

Indeed, it has been demonstrated a role of IGF-I signaling for maintaining glomerular integrity, restoring podocyte abnormalities, inhibiting podocyte apoptosis, and alterations in the glomerular basement membrane and the adjacent endothelial cell layer [140,363]