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A 2020 review by the Journal of the International Society of Sports Nutrition (JISSN) summarized over 70 studies and found that L-carnitine supplementation: Improves muscle oxygenation during exercise Reduces exercise-induced muscle damage Enhances recovery rates after intense workouts Provides mixed results for direct weight loss, although it consistently supports fat metabolism These findings help answer the question does L-carnitine work, especially when your goal is improving performance and recovery rather than relying on it as a standalone fat-loss supplement

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Increased levels of ROS in the blood and/or impaired antioxidant ability in chronically unwell patients with muscle loss have both been related to muscle wasting and ROS as powerful inducers of the UPS pathway, respectively