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1 Introduction Chlorogenic acid (CGA), also called caffeoylquinic acid (CQA), is a dietary polyphenol formed by the esterification of caffeic acid (CA) and quinic acid (QA) ( in vitro , and at 25 M, it reduces reactive oxygen species (ROS) to alleviate oxidative stress in intestinal cells ( eucommia , honeysuckle , and green tea ( The liver is vital for metabolism, the endocrine regulation, and immune response but is often exposed to irritants like viruses, medications, and chemicals ( Building on the aforementioned research findings, we propose the hypothesis that an optimal concentration of CGA confers protection to liver cells via its antioxidant properties