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In living cells, glutathione disulfide is reduced into two molecules of glutathione with reducing equivalents from the coenzyme NADPH

Furthermore, elevated ammonia concentrations induce cytotoxic edema in astrocytes, initiating a cascade of oxidative stress responses within the brain parenchyma that ultimately lead to neuronal dysfunction and neurological impairment 1

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Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications