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Although rare, alpha-lipoic acid may cause insulin autoimmunity (see Concerns and Cautions)

The -hydroxy isomer was formed as a major and the -hydroxy isomer as a minor product after incubation of acrolein with dG or calf thymus DNA [85]

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HBOT has also been implicated as a great tool for improving metabolic health and glucose regulation by improving peripheral insulin sensitivity (Wilkinson et al., 2012)