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In addition, most TEAEs in odevixibat-treated pruritus responders were mild or moderate, and none led to study discontinuation

The 3R allele for this variant is associated with a 24 fold increase in expression of the TYMS enzyme, as a result of the effect of this variant on the translation efficiency of TYMS

A recent study in Kenya found that several factors, including in utero exposure to efavirenz, but not DTG, were associated with lower neurodevelopmental scores in 1-year-old children exposed to HIV (WHO, 2021), and several studies have assessed the safety and efficacy of both RTG and DTG in children and adolescents, with a systematic review suggesting there are no safety concerns about treatment in this population (Townsend et al., 2022)

For example, histamine can increase the proliferation of rodent neural stem cells (NSC) or progenitors expressing histamine receptors during both embryonic and postnatal periods and increase the differentiation of adult NSCs into GABAergic neurons and the differentiation of fetal NSCs into glutamatergic FOXP2-positive neurons (Molina-Hernndez and Velasco, 2008