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11HSD1 activity appears to be inhibited by GIP (229), therefore suggesting the GIP is not a key player in mediating the post-prandial rise in cortisol

Its influence on glioma depends on the complex interplay of multiple factors, including tumor cell characteristics, the tumor microenvironment, and treatment modalities ( Figures 1 , 2

Johnsson, L

Furthermore, researchers often deplete endogenous GSH levels in cell models, using inhibitors of its synthesis like buthionine sulfoximine (BSO), to investigate the role of the glutathione system in mediating the cytotoxicity of specific drugs or environmental toxins