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Paclitaxel-resistant human ovarian cancer cells have mutant -tubulins that exhibit impaired paclitaxel-driven polymerization

RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3

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For an orally administered drug, use the following equation: If F is significantly less than 100%, the drug dose must be increased to achieve systemic drug concentrations similar to the IV formulation: If the oral formulation of a drug has a mean bioavailability of 50%, the drug dose must be doubled to achieve the same concentrations in plasma as achieved using the IV formulation