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On the other hand it is known that glutamine, the most abundant free amino acid in blood, is uptaked by tumor cells and converted into -ketoglutarate (-KG) that fuels the tricarboxilic acid (TCA) cycle and OXPHOS in tumor mitochondrial

Together, these findings support a model in which GSTs exert bidirectional control over pyroptosis with GSTM1 and GSTP1 dampening inflammasome execution, whereas GSTO1 derepresses inflammasome assembly

doi: 10.1128/mBio.00227-16 111 Sousa-FigueiredoJCBetsonMAtuhaireAArinaitweMNavaratnamAMDKabatereineNBet al

This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA