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9 Humans with lower levels of ROS such as patients with chronic granulomatous disease (CGD) than normal persons are also more susceptible to autoimmune disease

There exist some studies on Nrf2, a key factor of oxidative stress, but on the one hand, Nrf2 has preventive oxidative and anti-inflammatory effects on normal cells, on the other hand, it can promote tumor metastasis and induce drug resistance [250, 251]

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

Activated Caspase 9 can further activate Caspase 3, a critical effector enzyme in apoptosis