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Enolase (ENO1) is an important enzyme that may be necessary for MET activation, through hepatocyte growth factor (HGF) and transphosphorylation of low-density lipoprotein receptor-related proteins (LRP5/6) coupling with the coreceptor Frizzled, which are together bound by the prorenin receptor (PRR), which acts as an adapter between the receptor complex and the ATP-driven pump V-ATPase

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Zhiganova and Radkova (2025) study also revealed a trend toward a decrease in the frequency of the non-functional *6 allele (0.4% vs