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Vitamin B12 deficiency has been associated with peripheral neuropathy and even cognitive deficits, especially in older adults and those with HIV/AIDS, where it supports nerve function and assists in the maintenance of myelin sheath integrity

Diagnosis typically includes testing for anti-intrinsic factor antibodies (and sometimes anti-parietal cell antibodies)

However, copper peptides should not be mixed directly with high-dose vitamin C or strong AHA/BHA formulations in the same application step, as these can chelate copper ions and reduce efficacy

Evidence affirms the role of Cbl as a regulator of redox homeostasis and the connection between Cbl deficiency and oxidative stress