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Since the 1950s, the prevalence rate of SLE gradually increased from 63.2% to 91.4% until the early 2000s, with a survival rate of 10 years ( 2 ROS mechanisms underlying SLE 2.1 Oxidative metabolism in SLE Numerous mechanisms have been proposed for the cell death underlying tissue damage and immunological dysregulation in SLE ( Figure 1 ), but more research works are anticipated for a better understanding

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See David Cameron, New Study Validates Longevity Pathway, Harvard Medical School News (March 2013) ( pathway)