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Excessive autophagy contributes to neuron death in cerebral ischemia

tingling, numbness or pain

The auto-regenerative multienzyme activity of CeNPs, including superoxide dismutase [46, 47] and catalase [48], has attracted significant attention among researchers in the field of biomedical science in recent years

An alternative model of PHD regulation proposes that increased mitochondrial O 2 consumption reduces cytosolic O 2 availability to the PHDs, which can inhibit PHD activity and lead to HIF accumulation