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8.1 MSC and apoptosis Nishikawa and the team discovered that the DSS-induced colitis mouse model showed higher concentrations of caspase-3-positive cells and apoptotic nuclear cells in the colon sections and increased colon inflammatory cytokines, leading to decreased intestinal tight junction proteins such as claudin-2 and occludin (253)

For example, patients who have severe joint damage might find limited relief from injections, making them candidates for more advanced treatments like surgery

RNA was isolated from whole blood as outlined by the Tempus Spin RNA Isolation Kit protocol (Applied Biosystems) and quantified using a NanoDrop (ND-1000 Spectrophotometer)