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The oxidation states of the low-potential clusters are the oxidized [2Fe 3+ , 2Fe 2+ ] and the reduced [Fe 3+ , 3Fe 2+ ] forms, while the oxidation states for the high potential clusters switch between the reduced [2Fe 3+ , 2Fe 2+ ] and the oxidized [3Fe 3+ , Fe 2+ ] forms

The perhydroxyl radical (HOO) is another protonated form of O2 that starts the peroxidation of fatty acids (114)

Indeed, recent findings correlate the effects of curcumin on the Nrf2 pathway with its properties as an autophagy inducer since autophagy activation appears to be essential in regulating the effects of the Nrf2 pathway [123]

Science 240: 793796