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Furthermore, the orphan nuclear receptor 77 can bind to the promoter region of eNOS, enhancing NO production

In a trial involving 46 cancer patients, those who received selenium (200 mcg) and vitamin E (400 IU) had less cisplatin-induced kidney toxicity than those who received placebo (Hemati 2012)

Under the joint regulation of existing mitochondrial nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), new mitochondria are synthesized to replace damaged mitochondria, so as to repair mitochondrial structure, maintain mitochondrial function, increase antioxidant effect, reduce pathological oxidative stress and promote ATP production to meet the metabolic needs of eukaryotic cells under physiological and pathological conditions (Popov, 2020

Risks such as infection or allergic reaction are rare and usually mild