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Excessive copper ions (Cu(II)) may generate ROS, which mediates oxidative damage to lipids, proteins, and DNA

doi: 10.2478/intox-2014-0009 121 JeyachandranS.ChellapandianH.ParkK.KwakI.-S

This was further supported by the study where T-lymphocytes without functional GPX4 were not capable of clonal expansion and did not protect against choriomeningitis virus or parasitical Leishmanias infection [23]