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Multiple human, animal, and cellular studies converge on the view that mitochondrial dysfunction, oxidative stress, and impaired mitophagy lead to leakage of mtDNA into the cytosol and extracellular space, where it activates innate immune sensors and sustains chronic inflammation

In another, a lifespan trial in Swiss-derived SHR mice (1 g/mouse per month) reported no changes in food intake or body weight, while chromosomal aberrations decreased and maximum lifespan increased [7]

The bulk of BPC-157 research has focused on tissue repair (tendon, muscle, ligament, bone), gastrointestinal protection (ulcer models, IBD models, gut-brain axis), wound healing acceleration, and neuroprotection

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