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Another study demonstrated that MBP and the number of myelinating oligodendrocytes were decreased in 6-month old triple transgenic mice (3xTg-AD), the number of immature oligodendrocytes remained unchanged and mature non-myelinating cells were increased [29]

To evaluate the functional significance of these spine changes Nle1-AngIV and Dihexa stimulated hippocampal neurons were immunostained against the glutamatergic presynaptic marker VGLUT1 (Balschun, Moechars et al