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Signaling by hepatocyte growth factor in neurons is induced by pharmacological stimulation of synaptic activity

Oral capsules and sublingual formulations are available, though systemic bioavailability may differ from injectable forms whether oral BPC-157 can reach distant injury sites at therapeutic concentrations remains an open question

ACTH adrenocorticotropic hormone AD Alzheimer's disease ALLO allopregnanolone AMPA -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ANT adenine nucleotide transporter protein BBB blood-brain barrier BNST bed nucleus of the stria terminalis CB1 cannabinoid receptor 1 CICR Ca 2+ -induced Ca 2+ release CNS central nervous system DA dopamine DAT dopamine transporter DAT KO dopamine transporter knockout DHEA dehydroepiandrosterone DHEAS dehydroepiandrosterone sulfate GABA gamma-aminobutyric acid GAD generalized anxiety disorder GLIC Gloeobacter ligand-gated ion channels GnRH gonadotrophin-releasing hormone HPA axis hypothalamic-pituitary-adrenal axis HRSA Hamilton Rating Scale for Anxiety IL-6 interleukin-6 L-Type VGCC L-type voltage-gated Ca 2+ channel LTD long-term depression LTP long-term potentiation MCI mild cognitive impairment NMDA N-methyl-D-aspartate OATPs organic anion transporting peptides ORAI1 Ca 2+ release-activated Ca 2+ channel protein 1 PAHS pregnanolone hemisuccinate pCREB phosphorylated CREB PET positron emission tomography PCOS polycystic ovary syndrome PREG pregnenolone PregS pregnenolone sulfate PTSD post-traumatic stress disorder PV parvalbumin PXR pregnane xenobiotic receptor P450 scc cytochrome P450 side chain cleavage sEPSC spontaneous excitatory post-synaptic currents 5-HT serotonin SSRIs selective serotonin reuptake inhibitors StAR protein steroidogenic acute regulatory protein STIM1 stromal interaction molecule 1 THDOC tetrahydrodeoxycorticosterone TRH thyrotropin-releasing hormone TRP channels transient receptor potential channels TSPO translocator protein VDAC voltage-dependent anion channel

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