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Future research can focus on exploring the optimal ratios and combination strategies of different functional factors

Safety of dietary supplementation with arginine in adult humans 4

The ability to switch between glucose and fat metabolism is a key feature of metabolic flexibility in cold-adapted populations (103)

This work was also supported by Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0714 to H.T.), Chongqing Talents Plan for Young Talents (CQYC201905071 to S.P.), the strategic Priority Research Program of the Chinese Academy of Sciences (XDB39000000 to B.Z.), Youth Thousand Talents Plan (H.Z.), Shanghai Pujiang Program (16PJ1407400), and the National Key R&D Program of China (2019YFA0802804)