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However, in the United States, lacking definite data about susceptibility to clarithromycin, metronidazole, and levofloxacin, we should assume resistance is present and use a 4-drug regimen (eg, concomitant therapy or bismuth quadruple therapy)

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Former FDA Commissioner Marty Makary who resigned in May was also highly critical of FDA advisory panels, complaining that they were expensive, time-consuming and subject to too many financial conflicts