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GMP manufacturing challenges The production of NDDS requires precision methods such as microfluidics, solvent evaporation, and ligand conjugation, each demanding specialized infrastructure and technical expertise

It resembles the human gene in that it contains 12 exons, is expressed broadly in many tissues with the highest expression levels in lung, ovary, and subcutaneous fat pads (72, 73), and is 86% homologous with the human gene ( however, there are only three predicted isoforms and no isoform, other than the classical one, have been found for murine Hdc (72)

Results are usually progressive and require maintenance treatments or supplements to sustain brightness

doi:10.1007/s40292-019-00324-6 Wong RH, Berry NM, Coates AM, et al