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doi: 10.1016/j.jff.2020.104102 64 LiuHZhouM

These perturbations are dose-dependent, often manifest first in metabolic or enzymatic function and substrate utilization before major shifts in diversity or taxonomy ( 3 ENMs and human microbiome The human gut microbiota is a complex community of trillions of microorganisms, primarily bacteria that live in the gastrointestinal tract, especially the colon

These approaches can be broadly categorized according to their target, including regulators of oxidative stress, lipid peroxidation, iron dysregulation, DAMP-mediated inflammation, profibrotic cytokines, and ECM remodeling ( Table 1 )

Despite being considered the gold standard, the last Cochrane meta-analysis [14] has some objective limitations, that the present study has overcome (Table 3)