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Similarly, changes in cytokine levels are not necessarily specific for ME/CFS, and more likely indicative of immune activation with chronic inflammation, supported by observed elevation in the pro-inflammatory cytokines LT, IL-1, IL-1 and IL-6 in ME/CFS compared with controls [49]

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Gut and inflammation: Individuals with persistent digestive discomfort where gut barrier support is clinically relevant, people with suspected gut-inflammation overlap contributing to fatigue or poor systemic recovery, and those with a history of NSAID-related gut irritation

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