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Analogously, in the context of OA, it is speculated that local ferroptosis in joints may release metabolites such as pro-inflammatory factors and LPO into the bloodstream, thereby regulating the compositional and structural features of the gut microbiota

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This is particularly relevant given that clinical trials, such as the Slovakian High Tatras Spa Trial (NCT05178225), have specifically utilized ubiquinol to target post-COVID-19 syndrome, aiming to improve platelet mitochondrial bioenergetics and decrease systemic oxidative stress

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