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52 These methods take advantage of the fact that macrophages play a key role in the progression of RA (by producing pro-inflammatory cytokines) and that nanoparticles can be consumed by macrophages via leaky inflamed capillaries into arthritic joints, a phenomenon known as increased permeability and retention (EPR)

This is part of why longevity researchers have taken interest in it

The animal study was approved by Institutional Animal Care and Use Committee - University of Southern California

The resulting AKT degradation relieves its suppression on cuproptosis-related gene expression, leading to upregulation of DLAT, PDHB, and SLC31A1, which are essential for cuproptosis execution