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Thus, multi-step isoleucine catabolism enzymes, including the BCKDH complex, are present and active in the nuclei of PDA cells

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Although small-molecule PHGDH inhibitors effectively suppress tumor proliferation in preclinical models [52, 53], their therapeutic index may be limited by the essential physiological role of de novo serine synthesis in the central nervous system [54]

Research on underutilized or neglected legume fractions (e.g., by-products) remains limited, and the effects of common processing and household food-preparation techniques on polyphenol stability and release are not yet fully characterized