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Periorbital wrinkles, hydration, and skin elasticity improved at 4, 8, and 12 weeks in the collagen supplement group compared with baseline or placebo-control values

Although numerous preclinical studies have demonstrated significant therapeutic potential of targeting ferroptosis pathwayssuch as using iron chelators, modulating GPX4 activity, or inhibiting lipid peroxidationrecent clinical trial results indicate that strategies aiming solely to reduce iron accumulation may have limited efficacy in clinical practice

Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids