definition of glutathione peroxidase Frontiers The Selenoprotein Glutathione Peroxidase 4:

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In neurodegenerative diseases such as Alzheimers disease, the decrease in the function of this complex impairs the clearance of abnormal protein aggregates, thereby accelerating neuronal degeneration ( The class III PI3K/Beclin1 complex plays a central role in the regulation of autophagy, making it a promising target for drug development and a potential therapeutic strategy

doi: 10.1016/j.ccell.2020.10.001 321 ParthasarathyGChenJChenXChiaNOConnorHMWolfPGet al

Expand this to the fact that no two individuals are exposed to the same toxins at the same levels at the same times in their lives, and we find it even more difficult to create a solid recipe for how an MTHFR mutation will or will not affect each person