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Keywords: Neurodegeneration, Alpha-synuclein, Lysosomes, Fission, Fusion, Reactive species, Cellular bioenergetics, Pharmacological agents Highlights Autophagy is a lysosomal-mediated intracellular protein degradation pathway

However, excessive iron accumulation can lead to ferroptosis, which is morphologically, biochemically, and genetically distinct from other forms of cell death, including pyroptosis, apoptosis, and autophagy ( 2+ accumulation, lipid peroxidation, and restore the expression GPX4, ultimately protecting against MIRI via regulating ferroptosis ( Accordingly, we performed bioinformatics analysis to identify the DEGs related to ferroptosis