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If these disordered regions are large, they can negatively impact the pLDDT of nearby ordered regions and lead to folds differing from the experimentally determined structure, as in the example of the SM domain

Dikkala PK et al

The meaning and use of the area under a receiver operating characteristic (ROC) curve

Reductive stress induced by excessive levels of reduced NAD + (NADH), reduced NADP + (NADPH), and GSH is as harmful as oxidative stress and is implicated in many pathological processes