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24 however, PLMS are also commonly seen in the general population (especially the elderly), 25 in other sleep disorders, such as obstructive sleep apnoea, narcolepsy and REM behaviour disorder, and in non-sleep disorders including Parkinsons disease and other synucleinopathies

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These proteins inhibit apoptosis by binding to and neutralizing pro-apoptotic factors such as Bax and Bak, preventing their oligomerization and subsequent increase in mitochondrial outer membrane permeability, thereby promoting neuronal survival (104)

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