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Description

Through the suppression of pro-inflammatory mediators and antioxidant actions, HO-1 and the products of heme degradation are able to reduce inflammation and possibly diminish the phenotypic expression associated with obesity

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Clinical Application: While not FDA-approved for anti-aging or performance enhancement, IGF-1 LR3 is used off-label for tissue regeneration, metabolic enhancement, and muscle growth under clinical supervision

Consequently, MEF2C knockdown experimentsevidenced by reduced protein expression in Western blot and loss of nuclear localization in immunofluorescenceresult in decreased GPX4 levels and increased ferroptotic susceptibility in airway epithelial cells (114)