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* Correspondence: Yan Wang [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1016/j.ctim.2022.102819 150 SuMZhaoWXuS

Abstract Bladder cancer remains a significant global health concern, with environmental carcinogen exposureparticularly from tobacco-derived compounds such as aromatic amines, polycyclic aromatic hydrocarbons (PAHs), and nitrosaminesrecognized as a primary etiological factor