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whereas nasal brushing to access the olfactory mucosa has lower accuracy, and the sampling method requires a rigid scope and otolaryngologist to access the deep structures 102

PloS Negl Trop Dis (2018) 12(12):e0006968

In prolonged vasoplegia, the vasoconstrictive effect of intrinsic hormones (adrenaline, noradrenaline, arginine vasopressin, and angiotensin II) is reduced through a combination of hormone depletion, desensitization of adrenergic receptors, and smooth muscle cell hyperpolarisation [12]